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Is coumadin and xarelto the same drug company have been involved in a series of lawsuits about their use for several years. Dr. Robert Zajac, who directs clinical research and development for Wyeth, the maker of two medicines, said in an email that the products are safe and approved for patients without heart problems. He did not answer questions about a lack of data on the effects drugs heart, such as whether they could damage it. In addition to the heart issues that were mentioned at a drug committee hearing of the FDA last October, there are other ways the drugs have been linked to the heart, including a study done by Dr. Andrew Vickers in May 2002 the Journal of American College Cardiology, which showed an increased risk of heart failure associated with the use of drugs. It is likely that many drugs are similar enough that the same problems would happen in a heart with one drug or another. The question, however, is how common those interactions are. Photo As with aspirin, researchers say that the two most common problems associated with blood coagulants are heartburn and gastrointestinal problems. For people with heartburn, the best treatment is often medications called acid-suppressant agents, which can reduce the stomach acid in and prevent heartburn. the gastrointestinal disorders of blood coagulants, doctors tend to use antiarrhythmics, which can reduce the heart's rate. Advertisement Continue reading the main story At a meeting of the American Heart Association in January 2009, Dr. William Miller, associate clinical professor of medicine and at Stanford, presented research he did with Dr. Robert B. Weisman, M.D. That found heart failure in about 20 percent of the patients with blood coagulants had an arrhythmia. "I think heart failure is one of the most troubling things for patients to discuss with their doctors," Dr. Miller said. "I wish it could be avoided, but the reality of situation is that some them are more likely to develop heart failure than other people. And the ones who don't will probably need more intensive therapy." But Dr. John Tarnopolsky, an associate professor of medicine at the University Wisconsin and one of the researchers who first started pointing to the cardiac problems in drugmakers' blood coagulants, warns that some of the patients who need treatment for their heart troubles might end up on the same drugs as those who do not, which could be damaging to the heart in turn. Newsletter Sign Up Continue reading the main story Please verify you're not a robot by clicking the box. Invalid email address. Please re-enter. You must select a newsletter to subscribe to. Sign Up You will receive emails containing news content, updates and promotions from The New York Times. You may opt-out at any time. You agree to receive occasional updates and special offers for The best drug store in new york city New York Times's products and services. Thank you for subscribing. An error has occurred. Please try again later. View all New York Times newsletters. A few months later, Dr. Miller, Mr. Weisman and Tarnopolsky received a letter from Wyeth, the first of which suggested that Wyeth planned to reduce the size of heart problem and reduce the frequency intensity of other heart problems in at least some of its coagulant patients. Mr. Weisman was also advised in the first letter not to take other medications that could cause heart problems. Dr. Srinivasan is now investigating the heart problems that have caused so many patients to be switched from another treatment. His initial findings suggest that the new drugs may actually increase some of the heart problems that patients were already having. While there is no way to know for sure what is happening with the medicines, Dr. Srinivasan says his preliminary research does suggest that if patients switch from other blood coagulants to the new ones and are already taking aspirin or other medications, the drugs increase risk of heart problems. But that is only a first hint because so many other health conditions must combine with the drugs, Dr. Srinivasan said. "A lot of these drugs act together," he explained. "We really don't know how this happens." While Wyeth has declined to discuss the new studies, an executive of the company said recently in an interview, that he was unaware of any other studies Wyeth's drugs. And when asked, it is Wyeth that now using the drugs in clinical trials. In a written statement, Wyeth said the new studies are important because doctors know that they have a "special responsibility to their patients not change drug treatment once a patient has been prescribed medications for a condition." The company added: "It is our goal to have these safety studies done, as soon possible, and, where"
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Coumadin is used for treating and preventing harmful clots that may occur in the veins (venous thrombosis), in the lungs (pulmonary embolism), with a type of abnormal heartbeat (atrial fibrillation), or following a heart valve replacement.
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